Stem Cell Engineering

CD Biosynsis provides comprehensive stem cell engineering services to facilitate the cutting-edge research of synthetic biology researchers around the world.

Introduction to Stem Cell Engineering

Stem cells are essential for tissue development and regeneration. Stem cell differentiation requires strict temporal and spatial control of gene expression of lineage-specific transcription factors. The complex coordination of internal and external signals that control cell behavior plays a crucial role in determining the fate of stem cells. Stem cell engineering is the interface of engineering with the world of stem cells. It has emerged over the past decade as an important field of research and application.

With the rapid advances in molecular biology and bioinformatics, synthetic biology enables the design and construction of the desired functionality within biological systems. Stem cells can be programmed with artificial decision-making abilities. Genetic circuits that can dynamically control gene expression are used in stem cell engineering to drive stem cell fate decisions by pushing their differentiation into desired lineages. Combining synthetic biology with stem cell engineering can help facilitate more robust tissue engineering outcomes and offer therapeutic applications.

Figure 1. Cell signaling networks as the key to engineering multicellular self-organization. (Johnson M B, et al., 2017)

Applications of Stem Cell Engineering in Synthetic Biology

• Regenerative medicine
• Tissue engineering
• Immunotherapy
• Stem cell therapy

Service Offering

CD Biosynsis provides our customers with comprehensive and high-quality stem cell engineering services using our powerful synthetic biology toolbox to fully meet their requirements. Our services include but not limited to the following:

Genome Editing

Genome editing requires an in-depth understanding of the complex genetic functions of complete genome sequences. It can be used to precisely manipulate genome sequences to meet the design requirements of new biological systems. CD Biosynsis provides a comprehensive genome editing toolbox for stem cell engineering to meet the individual needs of our customers.

Stem Cell Reprogramming

Synthetic biology tools, such as genetic circuits and synthetic transcription factors, enable stem cells to be reprogramed and differentiated into specific cell types to achieve desired cellular outcomes. CD Biosynsis offers advanced stem cell reprogramming technologies and high-quality services to support synthetic biology research.

CD Biosynsis has developed a comprehensive portfolio of stem cell engineering services. We are fully committed to providing our customers with tailored solutions to help them overcome the challenges in synthetic biology and bring diverse creative ideas to fruition.

If you are interested in our services, please contact us for more details.

References

1. Johnson M B, et al. Engineering multicellular systems: using synthetic biology to control tissue self-organization. Current opinion in biomedical engineering, 2017, 4: 163-173.
2. Healy C P & Deans T L. Genetic circuits to engineer tissues with alternative functions. Journal of Biological Engineering, 2019, 13(1): 39.

Please note that all services are for research use only. Not intended for any clinical use.