Strain Engineering for Tyrosine

CD Biosynsis is dedicated to the redesign and global optimization of tyrosine biosynthetic pathways using advanced biotechnology to improve tyrosine production.

Background

Tyrosine is an important essential amino acid that plays an important role in the growth, development, and metabolism of humans and animals, and has been widely used in the food, feed, pharmaceutical, and chemical industries. Traditionally, tyrosine is mainly produced by protein hydrolysis and enzymatic reaction. However, both of these methods require limited sources of materials and have more complex synthesis processes. With the development of metabolic engineering and advanced biotechnology, the rational design and optimization of microbial metabolic pathways for the fermentation production of tyrosine have gradually become a hot research topic.

Figure 1. Tyrosine structure, synthesis, and metabolism. (Bross CD, et al., 2017)

What We Provide

Based on synthetic biology strategies, we are able to optimize the microbial production process of tyrosine and maximize the potential of the tyrosine biosynthesis pathway.

Deliverables

• Tyrosine producing microorganisms.
• Tyrosine.

How We Can Help

Development of Microbial Chassis for Tyrosine Production

Our professional microbial fermentation platform can provide tyrosine production services. Our metabolically engineered bacteria that are used for tyrosine production are Escherichia coli, Corynebacterium glutamicum, Brevibacterium flavum, and Bacillus subtilis. Please contact us directly if you have other chassis of interest for tyrosine production.

Global Optimization of Tyrosine Metabolic Pathways

We have been developing and applying new methods of metabolic engineering. We provide our customers with global optimization solutions for tyrosine production by microbial fermentation based on the results of a comprehensive analysis of the tyrosine synthesis pathway at the gene level, transcriptional level, and translation level. The following are specific services we offer for the global optimization of the tyrosine synthesis pathway.

• Module metabolic engineering optimization. We can split the tyrosine synthesis pathway into multiple synthesis modules and provide optimization services including promoter, terminator, copy number, and codon for each module as well as optimization services for the suitability of different modules.
• Global transcription engineering optimization. We can modify transcriptional elements such as transcription factors of strains based on global transcriptional machinery engineering to support our customers' modification for unknown metabolic pathways.

Applications of Tyrosine

CD Biosynsis can develop tailored tools and customized approaches to harness the power of synthetic biology to drive tyrosine production and meet the needs of customers in a variety of industries.

• As a nutritional supplement.
• As a raw material for complex amino acid injection.
• As supplementary raw material for pharmaceutical and chemical products.
• Used in the preparation of tissue culture media.

Want to Learn More?

CD Biosynsis provides the most comprehensive and efficient solutions for synthetic biology workflows. We are committed to helping our customers solve all problems encountered in tyrosine production to advance their applications in a wide range of fields. Each of our deliverables will undergo a rigorous quality inspection test to ensure the reliability and accuracy of the results. If you are interested in our services or have any further questions, please do not hesitate to contact us.

Reference

1. Schenck CA, Maeda HA. Tyrosine biosynthesis, metabolism, and catabolism in plants. Phytochemistry. 2018 May; 149: 82-102.

Please note that all services are for research use only. Not intended for any clinical use.