Strain Engineering for Elastin

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CD Biosynsis leverages our synthetic biology platform to help our customers explore economical ways to achieve efficient elastin production. Our distinguished scientists can provide expertise in synthetic biology to help our customers design and construct elastin with desirable or innovative properties for their applications in a wide range of fields.

Advantages of Synthetic Biology-Driven Elastin Production

Elastin is a biopolymer with highly elastic amino acid chains that provide resistance and elasticity to various tissues and organs of the body. Various elastin biomaterials developed based on elastin have a wide range of potential applications in biomedical, cosmetic, and tissue engineering fields. Generally, elastin biomaterials can be produced from natural, recombinant, or synthetic sources. However, there are many factors that hinder the large-scale and efficient production of elastin. The breakthrough advances in synthetic biology and metabolic engineering promise to overcome these obstacles in a completely new way. The engineering strategies and advanced tools of synthetic biology have greatly advanced the commercialization process of elastin and helped to design and construct powerfully engineered elastin biomaterials that can meet the needs of specific applications.

Figure 1. Diagram of the stages of elastic fiber formation. (Del Prado Audelo ML, et al., 2020)

What We Provide

CD Biosynsis combines our advanced technology platform in synthetic biology with emerging engineering concepts to help our customers overcome any problems that may arise in elastin production. Our dedicated scientists are committed to using the enabling technologies and tools of synthetic biology to develop powerful elastins that meet the needs of specific applications and achieve their large-scale, sustainable production.

Featured Services

We are able to add reactive amino acids or peptides to elastin sequences by DNA recombination technology and provide customized elastin peptide preparation services according to customer needs.
Based on the study of the molecular mechanisms of elastin formation, we are able to regulate cytokines that control elastin biosynthesis and catabolism through a tethered cascade of reactions.
We use the recursive directional ligation method to synthesize the gene encoding elastin-like protein.

Key Technologies

How We Can Help

Development of a Cell-free System for Elastin Production

Our expertise and advanced technologies in cell-free synthetic biology and protein synthetic biology have enabled us to develop cell-free systems as an alternative to elastin production. Our experienced scientists can optimize the biosynthetic pathway of elastin using advanced computational modeling or modular construction principles to help our customers achieve efficient production of elastins.

Synthetic Biology-based Strategies for the Improvement of Elastin Production

We use our advanced genetic engineering technology platform and the modular construction principle based on synthetic biology to modify and design targeted elastin products for specific applications, and to facilitate the subsequent development of various functional elastin-based biomaterials.
With our advanced technology and extensive experience in bacterial synthetic biology, fungal synthetic biology, and plant synthetic biology, our exceptional scientists can efficiently engineer bacteria, fungi, and plants to develop them into powerful synthetic biology chassis that can enhance elastin productivity. We have developed a variety of synthetic biology chassis that can be used for elastin production, including but not limited to Escherichia coli, yeast, and a variety of plants. If you are interested in developing additional synthetic biology chassis, please fill out our online inquiry form and tell us more about your project.

Applications of Elastins

CD Biosynsis provides customized solutions for synthetic biology-driven elastin production to meet the growing demand for elastin in the biomedical, tissue engineering and cosmetic fields.

For drug delivery.
For tissue engineering applications, such as the development of elastin-based cell scaffolds.
For the development of elastin-based materials for environmental remediation.
For the development of elastin-based wound dressings.
For the development of anti-aging skin care products.

Want to Learn More?

CD Biosynsis provides the most comprehensive and efficient solutions for synthetic biology workflows. We are committed to helping our customers solve all problems encountered in protein and peptide production to advance their applications in a wide range of fields. Each of our deliverables will undergo a rigorous quality inspection test to ensure the reliability and accuracy of the results. If you are interested in our services or have any further questions, please do not hesitate to contact us.

References

Del Prado Audelo ML, et al. Recent Advances in Elastin-Based Biomaterial. J Pharm Pharm Sci. 2020, 23: 314-332.
Grünberg R, Serrano L. Strategies for protein synthetic biology. Nucleic Acids Res. 2010, 38(8): 2663-75.

Please note that all services are for research use only. Not intended for any clinical use.

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