Strain Engineering for Natural Compound

CD Biosynsis designs and creates cell factories for target products based on the principles of synthetic biology. We design and modify the metabolic flow and regulatory networks at the whole-cell level, modularization, and regionalization of natural product synthesis pathways, and target product transport systems to improve the yield of cell factories.

Background

Natural compounds are considered a gift from nature to mankind, and more than the average drug small molecule is derived from natural products and their analogs. These include penicillin and adriamycin, which are of microbial origin, and artemisinin and morphine, which are of plant origin. However, natural products are very low in nature and difficult to obtain in large quantities through isolation. CD Biosynsis is dedicated to providing novel strategies for the large-scale production of natural compounds and the design and synthesis of small molecule compounds with new structures through synthetic biology techniques.

Figure 1. The overall biosynthetic pathways for producing representative natural products in Escherichia coli. (Yang D, et al., 2020)

Service Offering

With the elucidation of biosynthetic pathways of some important natural compounds, we are able to reconstruct the heterologous synthesis pathways of natural compounds in microbial chassis cells and systematically optimize the cell factories for the efficient production of natural compounds. We have successfully achieved the biosynthesis of the following natural compounds.

Strain Engineering for Resveratrol

Strain Engineering for Artemisinin

Strain Engineering for Astaxanthin

Strain Engineering for 3-Phenylpropanal

Strain Engineering for Flavonoids

Strain Engineering for Anthocyanidin

Why Choose Us?

• We have established a precision fermentation platform that can help our customers establish optimal microbial fermentation conditions and improve the yield of target products.
• We have advanced sequencing technologies that enable us to search for biosynthetic gene clusters using multi-omics information.
• We have experts in the field of synthetic biology who can provide you with the most efficient and high-quality solutions.

Solutions Related to Natural Compound Biosynthesis

• Synthetic Genomics
• Protein Synthetic Biology
• Bacterial Synthetic Biology
• Fungal Synthetic Biology
• Plant Synthetic Biology
• Chemical Synthetic Biology

Want to Learn More?

CD Biosynsis provides the most comprehensive and efficient solutions for synthetic biology workflows. We are committed to helping our customers solve all problems encountered in natural compound production to advance their applications in a wide range of fields. Each of our deliverables will undergo a rigorous quality inspection test to ensure the reliability and accuracy of the results. If you are interested in our services or have any further questions, please do not hesitate to contact us.

Reference

1. Yang D, et al. Metabolic Engineering of Escherichia coli for Natural Product Biosynthesis. Trends Biotechnol. 2020 Jul; 38(7): 745-765.

Please note that all services are for research use only. Not intended for any clinical use.